During the reign of Charles V, Spain began the conquest and colonization of America, moved by the news of the riches of this land. Hernán Cortés, commissioned to carry out this undertaking, he left Cuba on February 19, 1519 at the head of a fleet of 11 ships, with more than 600 people and numerous weapons (small cannons). He landed in Mexican land, he founded the city of Villa Rica de la Vera Cruz and took over the Captaincy General. Advanced on the native populations who submitted; burned the ships which had arrived to prevent them from escaping the repentant and entered the capital Aztec Tenochtitlan. The inhabitants resisted the invasion, killed their emperor Montezuma had declared vassal of the Spanish and Cortes revolted against the episode known as the sad night of Tenochtitlan. Cortes was forced to retire with his troops to Tacuba. The conqueror was able to reassemble his army and besieged Tenochtitlan on May 30, 1521. Owing to the resistance opposed by its inhabitants, the city was burned 113 later and thousands of Indians died. In October the following year, Cortés was appointed governor, captain general and chief justice of New Spain by the Emperor Charles V.
22 October 1520, Leo X crowned emperor Carlos I in the Palatine Chapel of the Cathedral of Aachen (Aachen) with the name of Charles V. Carlos was the fifth head of the Holy Roman Empire.